Chemical Synthesis and Antipseudomonal Activity of Al-Doped NiO Nanoparticles

Synthesis of efficient antibacterial agents has become extremely important due to the emergence antibiotic resistant bacteria. This is especially true for Pseudomonas aeruginosa , an opportunistic pathogen having ability rapidly develop resistance multiple classes antibiotics thus limiting efficacy approved clinical use. Aluminum (Al)-doped NiO nanoparticles are special interest their enhanced antipseudomonal properties at certain Al-doping levels. The composite hydroxide mediated (CHM) approach was opted synthesis pure nickel oxide (NiO) and Al-doped (Ni 1–x Al x O; = 5, 10, 15, 20, 25, 30 wt.%) nanoparticles. X-ray diffraction (XRD) technique used structural analysis these Morphology elemental composition were investigated by scanning electron microscopy (SEM) energy dispersive (EDX) spectroscopy, respectively. optical using UV-visible spectroscopy Kubelka-Munk Theory Tauc relation employed bandgap calculation activity representative assessed on multidrug-resistant P. strains. agar well disc-diffusion methods assess compared Interestingly, a gradual increase in observed with increasing concentration highest 15 wt.% concentration. Ni O comparable aztreonam antibiotic, primarily Gram-negative bacterial infections. Hence, it proposed that can be coating surgical devices, bone prostheses, medical implants, clothing pharmaceutical formulations as burn ointments produce antimicrobial effect.